Comparison of plaque burdens in Lenti-Nep and control-treated transgenic mice. a, Mean absolute values for amyloid staining in Lenti-Nep (Neprilysin) and control-treated animals on the contralateral and ipsilateral hemispheres (*p = 0.0007;^#p = 0.06; t test). Error bars represent SE. b, Relative ratios of ipsilateral (injected) versus contralateral (noninjected) plaque burdens. Nep, Lenti-Nep injected; GFP, Lenti-GFP injected; NepX, Lenti-NepX injected;INep, heat inactivated Lenti-Nep injected;Saline, saline injected. c, Scatter plot showing individual and the average relative values of the neprilysin (n = 12) and control (n = 14) groups; p = 0.000001 (t test) (TASD41: red squares, p = 0.01; J9M:blue circles, p = 0.004;t test). Error bars represent SD.