Overlapping Microarray Profiles of Dentate Gyrus Gene Expression during Development- and Epilepsy-Associated Neurogenesis and Axon Outgrowth

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Fig. 2.
Fig. 2.

Clustergraph analysis of gene regulation. A hierarchical clustering analysis of S-score gene expression data from three epileptogenic comparisons (SE lanes) and four developmental comparisons (DEV lanes) along with four control comparisons (CON lanes) is depicted. Red bands indicate increased gene expression after SE or during development, and green bands indicate decreased gene expression. A large cluster of genes downregulated during both development and epileptogenesis is most apparent; however, smaller subclusters of genes dissimilarly regulated are also evident, as is a separate cluster of genes upregulated during epileptogenesis that are unaffected during development. In CON lanes,red or green bands indicate increased or decreased gene expression between two identical samples.

  1. The Journal of Neuroscience vol. 23 no. 6 2218-2227
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