Overlapping Microarray Profiles of Dentate Gyrus Gene Expression during Development- and Epilepsy-Associated Neurogenesis and Axon Outgrowth

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Fig. 5.
Fig. 5.

In situ analysis of commonality gene expression over 28 d time course of epileptogenesis.In situ analysis of selected commonality genes was conducted over a broader time course of epileptogenesis. Various spatial and temporal patterns of gene expression and regulation were observed. For example, CD24 mRNA was prominently expressed in the SGZ of the dentate gyrus (other than a more global induction at 3 d post-SE that appears to be in glia and is relatively short-lived) and increased acutely after SE (left), whereas hippocalcin mRNA was more broadly expressed throughout the dentate gyrus and exhibited a more prolonged decrease that was greatest in the more mature regions of the cell layer (right). Scale bar, 100 μm.

  1. The Journal of Neuroscience vol. 23 no. 6 2218-2227
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