
Disruption of proper radial migration of cortical neurons by suppression of activities mediated by Pea3-Ets transcription factors. Representative coronal sections of E16.5 cerebral cortex showing positions of cortical descendants after electroporation of EYFP (A-C), DN-Erm (D-L), DN-Er81 (G-I), DN-Pea3 (J-L), and DN-Ets1 (M-O) at E13.5. C, F, I, L, O, Quantitative analyses of percentages of numbers of cells distributed at each zone. Each data point represents mean ± SEM counted in >30 sections. Images are obtained from >20 electroporated embryos. Scale bar, 0.2 mm. MZ, Marginal zone; CP, cortical plate; IZ, intermediate zone; SVZ, subventricular zone; VZ, ventricular zone.




