Figure 10.
The Y4 receptor agonist PP inhibits hypocretin cells. A, PP (0.1 μm) reversibly hyperpolarized the membrane potential in the presence of TTX (0.5 μm) in the bath. B, PP induced an inwardly rectifying K+ current (black trace) in hypocretin cells that was completely abolished by 1 mm Ba2+ in the bath (gray trace). This experiment was done with 16 mm extracellular K+.
