Neuropeptide Y Inhibits Hypocretin/Orexin Neurons by Multiple Presynaptic and Postsynaptic Mechanisms: Tonic Depression of the Hypothalamic Arousal System

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Figure 2.
Figure 2.

NPY inhibits spike frequency in hypocretin neurons. Representative traces showing the effect of 1 μm (A) and 0.1 μm (B) NPY on spontaneous spike frequency in typical hypocretin neurons are presented. C, Time course of the reversible inhibitory effects of NPY (1 μm) on spike frequency. D, Mean effect of NPY (1 μm) on spike frequency in hypocretin neurons (*p < 0.01; n = 12). This effect was partially reversible. Ctrl, Control; Wash, washout. E, Dose-response effect of NPY on firing rate.

  1. The Journal of Neuroscience vol. 24 no. 40 8741-8751
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