Agonist activation of mGluR1a stimulates Ral activity. Shown is mGluR1a stimulated binding of [³⁵S]-GTPγS to GST-RalA. HEK 293 cells expressing GST-RalA with either empty vector or FLAG-mGluR1a were incubated in the presence or absence of 30 μm quisqualate. The results represent the mean ± SE of six independent experiments. ^*p < 0.05 compared with GST-RalA alone.