Performance in an odor habituation task in PAC1^+/+ and PAC1^-/- mice. A, Time spent by PAC1^+/+ (n = 7) and PAC1^-/- (n = 8) mice sniffing a tube containing vanilla (trials 1-5) or strawberry (new) odor diluted at 10^-1. A control tube containing water was placed on the opposite corner of the cage (post hoc analysis, ^*p < 0.05; ^**p < 0.01 vs trial 1). B, Percentage of time spent investigating the odor during the different trials compared with the time spent investigating the vanilla odor during the first presentation (post hoc analysis, ^*p < 0.05; ^**p < 0.01; ^***p < 0.001 vs first trial). No differences were observed between PAC1^-/- and PAC1^+/+ mice. C, Percentage of odor discrimination (time sniffing the tube containing the scent/time sniffing control and scent tubes) for decreasing concentrations of vanilla scent (10^-1 to 10^-4) or novel scent strawberry (Str; 10^-1) tested at 1 week interval (post hoc analysis, ^**p < 0.01; ^***p < 0.001 vs vanilla 10^-4). The detection threshold for PAC1^+/+ and PAC1^-/- mice was identical.