Restoration of a normal performance level on the Rotarod in conditional SCA1[82Q] mice treated with dox beginning at 6 weeks of age. A, Performance on the accelerating Rotarod of 6 week gene-on—2 week gene-off mice compared with that of 8 week gene-on mice. Error bars indicate SEM. B, Performance on the accelerating Rotarod of 6 week gene-on—4 week gene-off mice compared with that of 10 week gene-on mice. Error bars indicate SEM. C, Performance on the accelerating Rotarod of 6 week gene-on—6 week gene-off mice compared with that of 12 week gene-on mice. Error bars indicate SEM.