Conditional SCA1[82Q] mice treated with dox beginning at 32 weeks of age failed to show evidence of significant improvement on the Rotarod. A, The Rotarod performance of 32 week gene-on—4 week gene-off and the performance of 36-week-old gene-on mice were equally compromised. Error bars indicate SEM. B, Although the Rotarod performance of 32 week gene-on—8 week gene-off mice was slightly better than the performance of the 40 week gene-on mice on trial days 3 and 4, it did not reach statistical significance. Error bars indicate SEM. C, The Rotarod performance of 32 week gene-on—12 week gene-off mice was better than the performance of 44 week gene-on mice on all four trial days, yet, it failed to reach statistical significance. Error bars indicate SEM.