Scheme showing sequences and mRNA target sites of V-siRNAs. All V-siRNAs have perfect homology (black rectangles) to sites within the open reading frame (region between open triangles) of targeted mRNA. National Center for Biotechnology Information accession numbers are provided for rat mRNA. Both sense (gray; 5′ to 3′) and antisense (black; 3′ to 5′) sequences of V-siRNAs used are shown.