Elevated plus-maze test on the Ad-1AP-antisense-injected mice. Top, The parameters indicate locomotor activity. Bottom, The parameters indicate exploratory anxiety-like behavior. Data are presented as mean ± SEM for 15-20 mice. One-way ANOVA for total entries: F_(1,33) = 13.4, p = 0.0009; for close entries: F_(1,33) = 15.5, p = 0.0004; for rearing: F_(1,33) = 20.4, p < 0.0001; for percentage open entries: F_(1,33) = 1.28, p = 0.27; for percentage open time: F_(1,33) = 0.68, p = 0.41. ^*Significant difference from Ad-track-injected mice (p < 0.05) by Student-Newman-Keuls post hoc test.