MPTP-induced TH cell loss in UCP2 TG and WT mice. A-D, Dopamine cell number assessed by tyrosine hydroxylase immunocytochemistry showed decreased number of cells in MPTP-treated WT and UCP2 TG mice (n = 5, 6). Scale bar: (in B) A-D, 50 μm. E, Stereological quantification of dopamine cell number revealed that UCP2 TG mice had significantly (p < 0.05) more surviving neurons than their WT littermates after MPTP treatment. ^*Significant with respect to wild-type controls. F, Analysis of striatal dopamine levels showed equally diminished dopamine levels after MPTP injections in transgenic and wild-type animals. Error bars represent SEM.