Developmental Changes in AMPA and Kainate Receptor-Mediated Quantal Transmission at Thalamocortical Synapses in the Barrel Cortex

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  Figure 4.
Figure 4.

Blockade of glutamate transport does not reveal a slow component to mEPSCfast. A, Example EPSC traces from a cell in normal extracellular medium (2.5 mm Ca2+, 0 mm Sr2+; top averaged trace), in Sr2+ (0 mm Ca2+, 2 mm EGTA; middle single trace), and Sr2+ plus TBOA (0 mm Ca2+, 2 mm EGTA, 20 μm TBOA; bottom single trace). B, Averaged evoked mEPSCfast in Sr2+ (left), Sr2+ plus TBOA (middle), and scaled and superimposed (right). Gray lines are single-exponential fits. C, Summary data for mEPSCfastτdecay and 10-90% rise time (left) and amplitude (right) in the presence of Sr2+ (black; n = 8) and in Sr2+ plus TBOA (gray; n = 8).

  1. The Journal of Neuroscience vol. 25 no. 21 5259-5271
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