Metabolism reduction in Alzheimer's disease measured by FDG-PET. The format is similar to Figure 1. The scale reflects the slope of the regression between CMRgl and dementia severity as measured by the MMSE. All included participants (n = 395) were demented (data from Herholz et al., 2002). Regions showing metabolism reduction as dementia severity increases include posterior cortical regions near precuneus extending into posterior cingulate and retrosplenial cortex, as well as to lateral temporoparietal regions.