Supplemental data

Files in this Data Supplement:

• supplemental material - Supplemental Figure 1: The mechanism of Ret activation and downregulation in sympathetic neurons is shown schematically. Formation of the GDNF-GFRα1-Ret signaling complex results in the translocation of Ret from non-raft domains into lipid raft membrane domains. Ret then moves out of lipid rafts, either alone or as a stable ligand-receptor complex, where it is ubiquitinated. The ubiquitinated Ret is then degraded predominantly by the proteasome.