IPSCs and EPSCs in layer IV and V pyramidal cells of younger wt and tg mice (P14–P16). A–D, The IPSC and EPSC peak amplitudes of layer IV (A, C) and V (B, D) were plotted against the intensity of stimulation for wt and tg mice at P14–P16. In both layers, the IPSC and EPSC peak amplitudes increased with increments of stimulus intensity in wt and tg mice. The insets show IPSC and EPSC traces by 1.0 mA stimulation. E, Averaged IPSC and EPSC peak amplitudes evoked by 1.0 mA stimulation in P14–P16 (left) and P21–P30 (right) mice. All data are represented as mean ± SEM for n = 10. **p < 0.01, Bonferroni’s test.