Table 2.
Summary of neuroprotection by NMDA receptor subunit-specific antagonists
| Neuroprotection | ||
|---|---|---|
| Antagonist | DIV 14 | DIV 21 |
| Ifenprodil | +++ | + |
| Ro25-6981 | +++ | + |
| Conantokin-G | +++ | +++ |
| Zinc | - | - |
| NVP-AAM077 | - | + |
-
Neuroprotection against HIV/MDM by NMDA receptor antagonists was categorized as 75-100% protection (+++), 50-75% protection (++), 25-50% neuroprotection (+), or 0-25% protection (-) for DIV 14 or DIV 21 hippocampal neurons.
