TNFR2 mediates the effect of increased IOP and of TNF-α on oligodendrocytes and RGCs. A, IOP elevation after angle closure by laser photo coagulation in wild-type, TNFR1^−/−, or TNFR2^−/− mice (n = 10 per group). Deletion of either TNFR gene does not alter IOP elevation. Solid line, laser-treated eye; dashed line, control eye. B, DiI-labeled RGCs (top panels; scale bar, 50 μm) or axons (bottom panels; scale bar, 20 μm) in wild-type or TNFR-deficient mice 4 weeks after inducing OH. C–E, Quantitation of DiI-labeled RGCs (C), optic nerve axons (D), or APC⁺ oligodendrocytes (E) 4 weeks after increasing IOP. **p < 0.01 and ***p < 0.001 compared with wild-type mice (n = 10).