Layer Positioning of Late-Born Cortical Interneurons Is Dependent on Reelin But Not p35 Signaling

Table 1.

Parameter estimates for fitted functions of the distribution of cell density as a function of cortical depth

n Gaussian fit [μ (95% CI)] Straight line fit [m (95% CI)] CI overlap
Dab1 wild-type GABA + BrdU, E12.5 (1C) 3 3.39(3.19, 3.61)
Dab1 mutant GABA + BrdU, E12.5 (1F) 3 6.89(6.59, 7.32) No
Reelin wild-type GABA + BrdU, E13.5 (2C) 3 −0.96(−1.80, −0.09) No
Reelin mutant GABA + BrdU, E13.5 (2F) 4 2.13 (0.61, 3.62)
Dab1 wild-type GABA + BrdU, E15.5 (3C) 3 2.17 (1.71, 2.71) No
Dab1 mutant GABA + BrdU, E15.5 (3G) 3 0.29 (0.10, 0.46)
Reelin wild-type GABA + BrdU, E16.5 (4C) 3 2.52 (1.60, 3.81) No
Reelin mutant GABA + BrdU, E16.5 (4G) 4 0.45 (−0.37, 1.29)
Dab1 wild-type nNos (5B) 5 −2.28 (−2.86, −1.70) No
Dab1 mutant nNos (5D) 5 1.44 (0.85, 1.98)
Dab1 wild-type calbindin (5F) 4 3.14(2.92, 3.36) No
Dab1 mutant calbindin (5H) 4 8.76(8.49, 9.14)
Dab1 wild-type calretinin (6B) 3 8.75(7.35, 12.51) Yes
Dab1 mutant calretinin (6D) 3 7.64 (7.11, 8.19)
Dab1 wild-type calretinin + BrdU, E15.5 (6E) 4 3.83 (3.20, 4.42) No
Dab1 mutant calretinin + BrdU, E15.5 (6F) 4 0.07 (−0.99, 0.77)
p35 wild-type GABA + BrdU, E15.5 (7C) 2 1.32 (1.10, 1.53) Yes
p35 mutant GABA + BrdU, E15.5 (7F) 2 0.82 (0.57, 1.11)
p35 mutant total GABA (7H) 2 0.69 (0.51, 0.87) No
p35 wild-type total GABA (7I) 2 −0.46 (−0.57, −0.36)
Wild-type E15.5 MGE transplanted into wild-type cortex (8C) 2 6.95(6.68, 7.21) Yes
Wild-type E15.5 MGE transplanted into Dab1 mutant cortex (8F) 2 6.66(6.42, 6.86)
  • The mean estimate is followed by the lower and upper limits of the 95% confidence interval (CI). In the first column, figure numbers are indicated in parentheses.

  1. The Journal of Neuroscience vol. 26 no. 5 1646-1655
Responses to This Article
Be the first to respond to this article
Advertisement