Altered synaptic and extrasynaptic sensitivity to THIP and LaCl₃ after CIE treatment. A, α4β3δ-preferring agonist (THIP) and antagonist (La³⁺) preferentially affect DG cell tonic current in saline-treated rats and synaptic currents in CIE-treated rats, respectively. Note the loss of La³⁺ effect on I_hold and increased THIP effect on mIPSCs in CIE rats. B, Summary graphs of total charge transfer of averaged mIPSCs (top graph) and I_hold (bottom graph) before and after THIP and La³⁺ application in saline- and CIE-treated rats. Each point is a mean ± SEM value from six neurons (1 rat per group). *p < 0.05 between saline and CIE groups; ^†p < 0.05 from pre-THIP value (two-way repeated-measures ANOVA).