Altered synaptic and extrasynaptic sensitivity to Ro15-4513 after CIE treatment. A, The α4β3γ2-prefering partial inverse agonist Ro15-4513 potentiates both mIPSCs and tonic current in DG neurons from saline-treated rats. Note the greater potentiation of mIPSCs and a reduction in I_hold by Ro15-4513 after CIE treatment. B, Summary graphs of total charge transfer of averaged mIPSCs (top graph) and I_hold (bottom graph) before and after Ro15-4513 application in saline- and CIE-treated rats (points are mean ± SEM values from 5–6 neurons; 2–3 rats per group). *p < 0.05 between saline and CIE groups; ^†p < 0.05 from pre-Ro15-4513 value (two-way repeated-measures ANOVA).