Chronic Intermittent Ethanol-Induced Switch of Ethanol Actions from Extrasynaptic to Synaptic Hippocampal GABAA Receptors

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Figure 7.
Figure 7.

Decreased tonic current potentiation, but enhanced mIPSCs potentiation, by EtOH in δ subunit-deficient mice. Summary graphs of changes in total charge transfer of averaged mIPSCs (right) and tonic current Ihold (left) before and after EtOH application in δ +/+ and δ −/− DG cells are shown. Each point represents a mean ± SEM value from 6–12 neurons, two mice per group. *p < 0.05 between +/+ and −/− groups; †p < 0.05 from pre-EtOH value (two-way repeated-measures ANOVA). Note the smaller total charge transfer of averaged mIPSCs in DG cells from δ −/− mice. Also note that 10 mm EtOH significantly potentiates mIPSCs from δ −/− but not δ +/+ mice.

  1. The Journal of Neuroscience vol. 26 no. 6 1749-1758
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