SC-CM reversibly inhibits evoked synaptic transmission. A, An example showing that SC-CM inhibits ESCs. The motoneuron was stimulated at the soma with an extracellular microelectrode at the frequency of 0.05 Hz. Samples of ESCs were recorded at different times when the neuromuscular synapse was in NCM, then SC-CM, and then NCM again. B, Summary of the changes of mean ESC amplitudes in SC-CM (n = 4). All ESC amplitudes were normalized with the mean ESC amplitude before SC-CM treatment. The horizontal bar indicates the period when SC-CM was applied. Each data point represents normalized mean ± SEM ESC amplitude.