Supplemental Data

Files in this Data Supplement:

• supplemental material - Supplementary Figure 1 LID-associated increase in ERK phosphorylation occurs in striatal medium spiny neurons. Immunofluorescence detection of DARPP-32 (which is specifically expressed in medium spiny neurons) (a, d) and phosphoThr202/Tyr204-ERK (P-ERK) (b, e) in the dorsal striatum of a highly dyskinetic mouse. (c, f) Double immunolabeling showing co-localization of DARPP-32 and P-ERK. Scale bars 200 �m (a-c) and 40 �m (d-f).
• supplemental material - Supplementary Figure 2 c-Fos immunoreactivity increases in dyskinetic mice. (a-d) Immunocytochemical detection of c-Fos in the dorsal striata of (a) sham-lesioned mouse (Sham), 6-OHDA-lesioned mouse with (b) low dyskinesia (L Dys) or (c) high dyskinesia (H Dys), (d) 6-OHDA-lesioned mouse treated with L-DOPA in combination with SL327 (75 mg/kg) (SL327). (e) 6-OHDA-lesioned mice were divided into low dyskinetic (L Dys) and highly dyskinetic (H Dys) according to their total AIMs score (see Methods) using the median value of 29 as cut-off. Histograms showing the number of c-Fos positive cells in the dorsal striata of sham-lesioned mice (Sham), L Dys, H Dys, and 6-OHDA-lesioned mice treated with L-DOPA in combination with SL327 (SL327). Data are means � SEM (n=3-7). ***p <_0.001 vs.="vs." l="l" dys="dys" one-way="one-way" anova="anova" followed="followed" by="by" bonferroni-dunn="bonferroni-dunn" test.="test." scale="scale" bar="bar" a-d="a-d" _40="_40" m.="m." _--="_--" end="end" desc="desc" suppl_fig_2.gif="suppl_fig_2.gif">