LTD is not affected in entorhinal cortex slices treated with Aβ42. A, LTD was reliably inducible by LFS (arrow) in vehicle-treated slices (open circles) and Aβ42-treated slices from WT mice (Aβ42, 200 nm; gray circles). The top horizontal dark bar corresponds to bath applied Aβ42. B, LTD was unimpaired in slices from RAGE-null mice. Error bars indicate SEM.