Contribution of I _M to SST mediated inhibition of epileptiform bursting. A , Representative traces showing SST inhibition of bursting when I _M is blocked with linopirdine (Linop) in wild-type and SST₂ and SST₄ knock-out mice. In wild-type and SST₄ knock-out mice, SST inhibits burst rate to a similar degree, but no inhibition is present in SST₂ knock-out mice. Experiments with and without linopirdine were done in different slices to avoid confounds caused by repeated applications of SST. Calibration: 0.5 mV, 10 s. B , Averaged data from the different mouse strains showing inhibition of epileptiform burst rate with and without linopirdine. With I _M blocked, SST inhibition is partially inhibited in wild-type mice, absent in SST₂ knock-outs, and unaffected in SST₄ knock-outs.