Table 3.
Proportion of wild types and SST3 and SST4 knock-outs reaching each seizure stage after kainate treatment
| Wild type | SST3 KO | SST4 KO | |
|---|---|---|---|
| Stage 1 | 100% | 100% | 100% |
| Stage 2 | 82% | 50% | 56% |
| Stage 3 | 27% | 50% | 22% |
| Stage 4 | 27% | 25% | 78%* |
| Stage 5 | 18% | 25% | 56% |
| Death | 0% | 0% | 33%* |
-
No significant differences were observed in the proportion of SST3 knock-out mice that reached each seizure stage compared with wild-type mice. For SST4 knock-out mice, a greater proportion reached stage 4 seizures than wild-type mice. In addition, seizure-induced mortality was observed in a significantly greater proportion of SST4 knock-outs than wild-type mice.
