A Double TRPtych: Six Views of Transient Receptor Potential Channels in Disease and Health
- Robert A. Cornell1,
- Michelle Aarts2,
- Diana Bautista3,
- Jaime García-Añoveros4,
- Kirill Kiselyov5, and
- Emily R. Liman6
- 1Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242,
- 2Department of Biological Sciences, University of Toronto, Scarborough, Toronto, Ontario, Canada M1C 1A4,
- 3Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720,
- 4Departments of Anesthesiology, Physiology, and Neurology, Northwestern University, Chicago, Illinois 60611,
- 5Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, and
- 6Department of Biological Sciences/Neurobiology, University of Southern California, Los Angeles, California 90001
- Correspondence should be addressed to Robert A. Cornell, 1-532 Bowen Science Building, Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242. robert-cornell{at}uiowa.edu
-
All authors contributed equally to the writing of this review.
Abstract
At the 2008 Annual Meeting of the Society for Neuroscience, a Mini-Symposium entitled “Contributions of TRP Channels to Neurological Disease” included talks from six heads of newly established laboratories, each with a unique research focus, model system, and set of experimental tools. Some of the questions addressed in these talks include the following. What is the role of transient receptor potential (TRP) channels in pain perception? How do normally functioning TRP channels contribute to cell death pathways? What are the characteristics of TRPpathies, disease states that result from overactive or underactive TRP channels? How are TRP channels regulated by signal transduction cascades? This review summarizes recent results from those laboratories and provides six perspectives on the subject of TRP channels and disease.
- cation channel
- melanocyte
- mucolipidosis type IV
- nociception
- pain
- TRP
- amyotrophic lateral sclerosis/parkinsonism dementia complex
- taste
- cell death
- lysosomal storage disease
- TRPA1
- TRPM5
- TRPM7
- TRPM8
- TRPML1
- TRPML3
- Copyright © 2008 Society for Neuroscience 0270-6474/08/2811778-07$15.00/0
