Recovery from IKlt inactivation and recovery from firing rate adaptation follow similar time courses. A, Recovery from IKlt inactivation. The top two traces show the current generated in response to voltage-clamp steps. Two sweeps with different recovery intervals are superimposed in black and gray. The bottom panel is a plot of the amount of recovery from IKlt inactivation versus recovery interval at −50 mV (n = 10), −60 mV (n = 8), −70 mV (n = 7), and −80 mV (n = 6). The dashed lines are single-exponential fits to the data. Error bars equal SE. B, Same layout as in A but for recovery from firing rate adaptation in hybrid-clamp mode. The dotted black and gray lines indicate times spent in voltage clamp (VC) and current clamp (IC) for the like-shaded traces. The bottom panel is a plot of the recovery of firing rate from adaptation versus the recovery interval at −60 or −70 mV (n = 8). The dashed lines are exponential fits to the data. C, Plot of the mean recovery time constants (from the exponential fits) versus the recovery voltage for IKlt inactivation (open triangles) and firing rate adaptation (filled squares) (*p < 0.01, Bonferroni's corrected t test). Error bars represent SE.
