Levels of plasma parameters of energy homeostasis and hormones affecting appetite in VGV mice. T4 (A) and corticosterone (B) levels of wild-type and VGV male mice at two different postnatal stages (3 and 6 weeks) were displayed as the mean ± SEM (n = 11–22). No significant change of serum T4 and corticosterone levels was observed in VGV mice at either stage (Mann–Whitney U test). Serum glucose (C) and insulin levels (D) (n = 24–43) as well as serum leptin (E) and active ghrelin (F) (n = 11–16) were also examined. Insulin levels of VGV mice were significantly decreased at 3 and 6 weeks (**p < 0.01; ***p < 0.001). Serum glucose and leptin levels of VGV mice were significantly decreased at 3 weeks (**p < 0.01; ***p < 0.001), but there was no difference at 6 weeks (p > 0.05). In contrast, active ghrelin levels of VGV mice were significantly increased at 3 weeks (***p < 0.001), but not at 6 weeks (p > 0.05).