Marciane Milanski; Giovanna Degasperi; Andressa Coope; Joseane Morari; Raphael Denis; Dennys E. Cintra; Daniela M. L. Tsukumo; Gabriel Anhe; Maria E. Amaral; Hilton K. Takahashi; Rui Curi; Helena C. Oliveira; José B. C. Carvalheira; Silvana Bordin; Mário J. Saad; Lício A. Velloso

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

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Figure 6.

Real-time PCR determination of TNF-α (A), IL-1β (B), IL-6 (C), and IL-10 (D) mRNA expressions in hypothalamic samples obtained from rats nonintracerebroventricularly canulated (CT), or treated intracerebroventricularly with diluent (DL), arachidic acid (C20:0), TLR4 receptor antibody plus arachidic acid (T4rAb+C20:0), TLR2 receptor antibody plus arachidic acid (T2rAb+C20:0) or PBA plus arachidic acid (PBA+C20:0) for 3 d. The results are presented as transcript amount, n = 5, and different letters mean significant differences between groups, p < 0.05.

The Journal of NeuroscienceSociety for Neuroscience

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

The Journal of Neuroscience Society for Neuroscience