Conditional Bursting Enhances Resonant Firing in Neocortical Layer 2–3 Pyramidal Neurons

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Figure 8.
Figure 8.

Effects of the SK channel blocker apamin on G(f). A, Typical effect of apamin on the fADP and mAHP, illustrated by the Vm trajectory after a single spike elicited by a 3 ms square current pulse added to IDC slightly below the rheobase. B, ISI histograms for a typical L2–3 PN stimulated with 5 ms exponential-filtered noise (σI = 0.18 nA) before and after wash in of apamin (100 nm). In each case, r0 was held at ∼10 Hz by adjusting IDC. C, Average G(f) in L2–3 PNs (n = 7) in control solution and in apamin, with r0 controlled at 10 Hz. D, Apamin increased the fraction of spikes in bursts. E, Apamin reduced the primary resonance frequency. F, Apamin reduced the strength of the primary resonance. G, Frequency-dependent subthreshold impedance magnitude (n = 4), determined by injection of chirp current (0–30 Hz in 60 s) with Vm set just below spike threshold by addition of IDC. Values are normalized by the impedance magnitude at 1 Hz. *p < 0.05.

  1. The Journal of Neuroscience vol. 29 no. 5 1285-1299
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