Cerebral Microglia Recruit Monocytes into the Brain in Response to Tumor Necrosis Factorα Signaling during Peripheral Organ Inflammation

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Figure 5.
Figure 5.

MCP-1/CCL2 via its actions on CCR2 mediates monocyte recruitment into the brains of BDR mice. A, Solid bars represent the percentage of total peripheral blood monocytes (PBMs)-expressing CCR2 in day 10 sham and BDR mice. Hatched bars represent the total number of CCR2-expressing PBMs isolated from day 10 sham and BDR mice. Error bars represent mean ± SEM of data from 6 sham and 9 BDR mice; *p < 0.05 versus sham controls. B, Solid bars represent the percentage of total brain microglia that express CCR2 in day 10 sham and BDR mice. Hatched bars represent the total number of CCR2-expressing microglia isolated from the brains of day 10 sham and BDR mice. Error bars represent the mean ± SEM of data from 6 sham and 9 BDR mice; *p < 0.05 versus sham controls.

  1. The Journal of Neuroscience vol. 29 no. 7 2089-2102
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