Processing Afferent Proprioceptive Information at the Main Cuneate Nucleus of Anesthetized Cats

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Figure 10.
Figure 10.

GABA and glycine exerted additive inhibitory effects over proprioceptive induced responses, and BiCu ejection unmasked a GABAA-dependent tonic inhibition. A–C, Same CL cell. A, GABA application was adjusted to leave only part of the dynamic response when tapping the muscle with an electric Von Frey probe (3), and then a 5 nA glycine ejecting current fully abolished the response (4). Notice that the cell showed an enhanced activity upon recovery from drug withdrawal (5) at the same muscle length as in the control condition (1, 2). B, Left, Antidromic activation; right, stimulation at two different sites (rvCN1; rvCN2), separated 500 μm from each other, synaptically activated the cell only from rvCN2. C, Subthreshold rvCN2 stimulation in the control condition (left panel) was well suprathreshold during BiCu ejection (right two panels), indicating that GABA exerted a tonic inhibition through GABAA receptors.

  1. The Journal of Neuroscience vol. 30 no. 46 15383-15399
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