A, CuZnSOD viral gene transfer to the SFO, but not gene transfer of the control virus expressing LacZ, blocks the increase in arterial pressure in mice receiving slow-pressor doses of AngII (600 ng · kg⁻¹ · min⁻¹). B–E, CuZnSOD viral gene transfer prevents the attenuation of the CBF response to whisker stimulation (B), and to endothelium-dependent vasodilators (C–E). F, AngII does not alter the CBF response to adenosine, with or without CuZnSOD viral gene transfer, attesting to the reactivity of the preparation (*p < 0.05 from respective saline group; ANOVA and Tukey's test; n = 6 per group).