NMDAR-mediated component of lemniscal EPSCs after the IONC. A, Representative traces of lemniscal EPSCs mediated by a sham fiber, an S-fiber in the IONC group, and a W-fiber in the IONC group. Several raw traces with different stimulus intensities are superimposed. B, Summary bar graphs showing the mean of amplitude of NMDAR-mediated (left) and AMPAR-mediated (right) EPSCs. n, number of fibers. C, Summary bar graph showing the mean of NMDAR/AMPAR ratios (+40/−70 mV) from single-fiber-mediated lemniscal EPSCs. n, number of fibers. D, Representative raw traces of pure NMDAR-mediated lemniscal EPSCs at holding potentials between +40 and −100 mV in 10 mV steps with <20 μm NBQX. E, Current–voltage relationships of pure NMDAR-mediated lemniscal EPSCs. The number of tested fibers was 9, 10, and 10, respectively, for sham fibers, S-fibers in the IONC group, and W-fibers in the IONC group. F, Representative traces of pure NMDAR-mediated EPSCs are normalized by their peak amplitudes. Peak currents were 671, 1321, and 261 pA, respectively, for a sham fiber, an S-fiber in the IONC group, and a W-fiber in the IONC group. G, Summary bar graphs showing the decay time constants of NMDAR-mediated EPSCs from each of three kinds of fibers. n, Number of fibers. All data are expressed as the mean ± SEM. Statistical significance was tested by two-tailed multiple t test with Bonferroni's correction following one-way ANOVA (B, C), one-way ANOVA (G), and two-way repeated ANOVA (E), respectively. **p < 0.01. n.s., Not significant.