The crosstalk between ERK and AKT signaling pathways is reciprocal in SMA spinal cord. A, B, Western blot analysis and quantification of ERK protein phosphorylation in control and SMA spinal cord explants in the presence or absence of either NMDA or the CREB inhibitor KG-501 (n = 3). C, D, Western blot analysis and quantification of Elk-1 protein phosphorylation in control and SMA spinal cord explants in the presence or not of NMDA and of the CREB inhibitor KG-501 (n = 3). E, F, Western blot analysis and quantification of AKT protein phosphorylation in control and SMA spinal cord explants in the presence or absence of either NMDA or the CREB inhibitor KG-501 (n = 3). G, H, Western blot analysis and quantification of SMN protein expression in control and SMA spinal cord explants in the presence or absence of NMDA or the CREB inhibitor KG-501 (n = 3). Data are displayed as mean ± SEM. *p < 0.05.