Oral Administration of a Small Molecule Targeted to Block proNGF Binding to p75 Promotes Myelin Sparing and Functional Recovery after Spinal Cord Injury

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Figure 12.
Figure 12.

LM11A-31 did not change NF and CSPG protein levels. A, NF and CSPG protein levels were not greatly affected by LM11A-31. Tubulin, a loading control, is also shown. B, Representative images from NF and GFAP immunohistochemistry at 42 dpi. The images in a and f were taken from the ventral regions of the laminectomy controls with the vehicle or LM11A-31 at 100 mg/kg. Scale bars, (for a—d) 20 μm; (for e, f) 75 μm. The experiments were repeated >4 times, and representative images are shown.

  1. The Journal of Neuroscience vol. 33 no. 2 397-410
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