CR protects structural synaptic and dendritic integrity. A, CR-mediated preservation of presynaptic terminals in CK-p25,CR animals as evidenced by SVP immunohistochemistry in the stratum radiatum of hippocampal area CA1. B, Quantification of A [one-way ANOVA (F_(2,8) = 8.99, p ≤ 0.01) followed by Tukey's post hoc tests; n = 3 for CON,AL and CK-p25,CR; n = 5 for CK-p25,AL]. C, CR-mediated preservation of the number of synapses in the hippocampus of CK-p25,CR animals as evidenced by transmission electron microscopy. D, Quantification of C. One-way ANOVA (F_{(2, 6)} = 24.84, p ≤ 0.01) followed by Tukey's post hoc tests; n = 3 mice each. E, CR-mediated preservation of the number of spines per given dendritic length in the hippocampus of CK-p25,CR animals as evidenced by Golgi impregnation. F, Quantification of E [one-way ANOVA (F_(2,22) = 23.31, p ≤ 0.01) followed by Tukey's post hoc tests; n = 7–10 dendrites per animal, 3 animals each]. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001 for Tukey's post hoc comparisons. All values are mean ± SEM. Scale bars: A, 100 μm; C, 0.5 μm; E, 2 μm.