Modulation of interregional connectivity. A, Basic structure of the model: face presentation drives FFA activity, which projects to the amygdala (AMY) that is bidirectionally connected with aPFC. B, Emotional control could modulate aPFC (orange) and amygdala activity (blue) either directly, on connections, or via other nodes. C, Overview representing all 24 models and their corresponding families within each factor. Each model contained the basic model with one orange and one blue connection. D, XP_k for each factor of the model selection for model families. For the aPFC factor, families 1 and 2 together show XP_k > 0.95. For the amygdala factor, XP_k > 0.95 is reached for families 1 and 2 together, all containing a modulation via the aPFC. These XP_k values are similar for non-carriers (medium gray), s-carriers (light gray), and across groups (dark gray). E, Best models (combined XP_k > 0.95) for the fMRI data across genotypes in which emotional control modulated the aPFC and aPFC modulated the amygdala. These models were averaged within subjects for parameter inference. F, Parameter estimates (±SEM) of the direct aPFC→amygdala connection. Non-carriers, but not s-carriers, showed significant inhibition of amygdala by the aPFC.