Upregulation of CBS expression. A, CBS protein expression was greatly enhanced in diabetic rats compared with age- and sex-matched CON rats (CON, n = 3; STZ, n = 4, *p < 0.05 compared with CON, 2-sample t test). B, CBS protein expression was not altered in N-DM rats compared with age- and sex-matched CON rats (CON, n = 3; N-DM, n = 3, p > 0.05 compared with CON, 2-sample t test). C, RT-PCR assays demonstrated a significant upregulation of CBS mRNA expression in T7–T10 DRGs in diabetic rats (CON, n = 6; STZ, n = 4, *p < 0.05 compared with CON, 2-sample t test).