Quantal properties, baseline Pr and depolarization-induced endocannabinoid signaling are not altered in ZnT3 KO mice. A, Top, Sample traces of mEPSCs from ZnT3 WT and KO mice. Cumulative probability plot of mEPSC frequencies shows that frequencies are not different between ZnT3 WT and KO mice (mean mEPSC frequency WT: 3.25 ± 0.60 Hz, n = 5; KO: 3.57 ± 0.73 Hz; n = 5, p = 0.74). B, Cumulative probability plot of mEPSC amplitudes shows that amplitudes are not different between ZnT3 WT and KO mice (mean mEPSC amplitude WT: 17.50 ± 1.2 pA, n = 5; KO: 16.7 ± 0.33 pA; n = 5, p = 0.54). C, Cumulative probability plot of mEPSC rise times showing that rise times are not different between ZnT3 WT and KO mice (mean mEPSC rise time: WT: 0.67 ± 0.06 ms, n = 5; KO: 0.59 ± 0.03 ms; n = 5, p = 0.3). D, Cumulative probability plot of mEPSC decay times showing that decay times are not different between ZnT3 WT and KO mice (mean mEPSC decay time WT: 1.44 ± 0.08 ms, n = 5; KO: 1.42 ± 0.07 ms; n = 5, p = 0.84). E, PPR is similar in ZnT3 WT and KO littermates (PPR WT: 2.13 ± 0.15, n = 7; KO: 2.16 ± 0.11, n = 7, p = 0.85). F, DSE is similar in ZnT3 WT and KO mice. Time course of DSE, induced by a 5 s depolarization to 10 mV (DSE WT: 33.5 ± 4.9% of control, n = 5; KO DSE: 35 ± 3.2% of control, p = 0.54). Summary data represent mean ± SEM.