Effects of treatment with 200 mg/kg ceftriaxone or saline on cue-induced cocaine-seeking behavior. Cue-induced cocaine seeking was significantly attenuated in ceftriaxone-treated long-withdrawal cocaine-seeking groups, with a greater effect in the extended-access group; no differences in responding occurred between saline-treated and ceftriaxone-treated short-withdrawal cocaine-seeking rats (*p < 0.05; ***p < 0.0001). Error bars indicate SEM. The number of animals is listed for each group. Note that cue-induced cocaine seeking was assessed in extinction test sessions in which lever presses led to contingent cue presentations but not cocaine.