Intentional AD is inducible only in the mice with high-level SCI. A, B, Representative pulsatile arterial pressure traces after applying colorectal distension or cutaneous pinch in mice at least 14 d after SCI or sham surgery (15–20 dpi). Under each trace, MABP and mean HR changes are quantified showing responses to colorectal distension (A) or cutaneous pinch (B). Arrows on each trace indicate the start and stop, respectively, for each stimulus. C, D, Quantification of MABP and mean HR changes in response to colorectal distension (C) or skin pinch (D). Baseline data (white bars) were calculated by averaging measured values over a 10 s period immediately before stimulation. Black bars represent peak BP values and corresponding HR measured during the time interval spanning stimulus onset until 5 min after cessation of stimulus. n = 6–8/group; *p < 0.05; **p < 0.01 versus baseline.