Selective β₂AR and GR antagonists reverse AD-associated chronic immune suppression in T3 SCI mice. Butoxamine (Butox; a selective β2AR antagonist; 5 mg/kg) and RU486 (a glucocorticoid receptor antagonist; 5 mg/kg) were injected intraperitoneally daily at 1–7 dpi and 14–28 dpi. All mice were immunized at 18 dpi with OVA (100 μg) 1 h after injecting drugs. Spleen weight (normalized to body weight) (A) and OVA-specific antibodies (B) were analyzed in sera at 28 dpi. n = 4–6/group; *p < 0.05; **p < 0.01.