Perivascular Fibroblasts Form the Fibrotic Scar after Contusive Spinal Cord Injury

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Figure 1.
Figure 1.

Col1α1-GFP+ cells are preferentially associated with larger blood vessels and express CD13 and PDGFR-β in uninjured spinal cord. Col1α1-GFP+ cells (A,F) express CD13 (B) and PDGFR-β (H), but not NG2 (C), nestin (D), CD45 (G), or markers for fibrocytes, neural cells, or immune cells (pictures not shown). Table lists percentage of Col1α1-GFP+ cells that express each cell type-specific antigen. LSFM reconstructions of spinal vasculature (LEL, red) in Col1α1-GFP mouse spinal cords show Col1α1+ cells (GFP, green) along large spinal vessels but not microvessels (K–M). E, Arrow refers to pericyte. Scale bars: A–J, 10 μm: K, L, 500 μm.

  1. The Journal of Neuroscience vol. 33 no. 34 13882-13887
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