Adult Neurogenesis Produces Neurons with Unique GABAergic Synapses in the Olfactory Bulb
- 1Laboratory for Perception and Memory and
- 2Integrative Neurobiology of Cholinergic Systems, Pasteur Institute, F-75015 Paris, France, and
- 3National Center of Scientific Research, Coeducational Research Unit, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 3571, F-75015 Paris, France
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Author contributions: M.T.V. and P.-M.L. designed research; M.T.V. performed research; M.T.V., L.G.H., and S.A.I. analyzed data; M.T.V. and P.-M.L. wrote the paper.
Abstract
Neuronal regeneration occurs naturally in a few restricted mammalian brain regions, but its functional significance remains debated. Here we search for unique features in the synaptic outputs made by adult-born granule cell interneurons in the mouse olfactory bulb using optogenetic targeting of specific neuronal ages. We find that adult-born interneurons are resistant to presynaptic GABAB-mediated depression of GABA release compared with interneurons born just after birth that exhibit strong GABAB neuromodulation. Correlated with this functional change, we found altered localization of the GABABR1 protein within adult-born granule cells. These results suggest that adult neurogenesis produces a population of functionally unique GABAergic synapses in the olfactory bulb.
- Received July 4, 2013.
- Revision received August 1, 2013.
- Accepted August 5, 2013.
- Copyright © 2013 the authors 0270-6474/13/3314660-06$15.00/0
