Basal synaptic transmission and long-term potentiation at SC-CA1 synapses are normal in Itsn mutants. A–C, Measurements of fEPSPs, afferent volleys, and paired pulse ratios in all genotypes revealed no significant differences in hippocampal basal synaptic physiology. D, Normalized fEPSPs during increasing stimulation frequency were indistinguishable between genotypes. E, F, Induction of LTP using HFS and TBS stimulation of SC-CA1 synapses were indistinguishable between genotypes.