Comparisons of motor, exploratory, and open field behaviors. A, Motor coordination task was measured by assessing the number of paw slips on a grid test. Itsn1 mutants (Itsn1^Gt/Gt and Itsn1^Gt/GtItsn2^−/− mice) showed impaired motor coordination (F_(3,45), = 11.91, p < 0.05). One-way ANOVA statistical tests were used to calculate individual p values. B, Exploratory coordination behavior was measured as forearm usage when standing on rear feet inside a vertical tube. There was no difference in the total number of rears in this cylinder test (F_(3,45) = 1.94, p > 0.05). C, Average distance traveled during open field task. No statistical differences were observed. D, Anxiety test was measured as time spent in open field zones. The results of an ANOVA with between-group factor Genotype and within-group factor Zone (outer, middle, and inner) revealed no significant interaction between Genotype and Zone (F_(6,96) = 1.40, p > 0.05). One-way ANOVA statistical tests were used to calculate individual p values.